that is subjective. let me speak for most of the parsers and say, any change is a big change when it comes to DPS.
for pete's sakes people just DONT clip the beginning of the parse. the fight starts when you HIT the friggin dummy! jeez
*hey styrak my man, let us engage in combat but i ask you kindly please do not hit me until i have all my juyo stacks up!*
*hey terror from beyond dude! wasup brother? can i put my 3 dots and my armor pen and my EP on you first before i Cull and then we can start the figtht? im sry bro i need to put my dots up first in order to do damages. thanks budddy!*