Well, I prrefer keybinds, but I most definitely don't use ALL keybinds. Some are just too impractical. Anything right of 7, is pretty much out of reach for me. So on skill bloated characters, the occasional skill placed on 8 or beyond (with or without modifier) will be clicked as it's simply faster and more tactful than letting movement go
Well not all is necessary. I don't keybind my buff or spells rarely used. For me, 7 is as far as I go with the numbers. Then I uses Shift and Alt as my modifiers. Then use Q,E,R,T,F,Z,X,C,V as my letters. All very easy to reach, and all work well with a shift, and alt modifier.