When I am solo in pug and see high ranked guild premade, I leave because its just wasting time and not fun. I play only for win and play for loosing its just not fun.
There is one and really only one solution of problem in this thread - /leave.
And if you are solo and faced premades- /leave.
And if you are solo and faced premades every time - /unsub.
Hope, BW will be glad with money of that hardcore premaders, but seems BW dont care about solo casual players. Well, there are plenty other good games.
Not all the time, I have been in mish mash groups that have been dominant against pretty much any premade I have come up against. So it does happen, and it does help if you have an Ops Leader who has communication skills, as this ultimately is where a win for a mish mash group will come from, if against a well drilled premade.
It would be nice if they had an in game communications server, that everyone can get into. This would then possibly lead to many of these premades being put to bed in the long run as communication is to me the key to any win, whether against premade or a mish mash group.