Yes to Missle Blast slow.
No to unlimited tramua probes. just allow it to be on 2 extra people
Yes to Run and Gun. Minor change: can only be used on tracer/powershot and maybe fusion missle. I could see a really annoying hybird with this if it stayed the way your have it now.
No to Cure change cleansing force dots would be to much sadly
Everything else seems fine to me I really do love the run and gun thing tho. I would love for them to make our threat dump drop roots when used.