I play SWTOR with a friend who is a bloke, and he pretty much plays all female toons - he prefers the female aesthetics. That is annoying though when his girl has better looking armour than my girl (I spent a lot of time and credits trying to get my girl looking better than his), but other than that, I don't think anything of it. He has recently made a male character, and that took a while to get used to! I think it was because he wanted to use the flirt options on all the females NPCs in the game
But it means nothing what gender character you play - you only get issues when the weird people fixate on a toon of the gender they fancy in real life, assuming its being played by someone of that gender. And that is just plain old creepy.