I've been having an issue like this since I got into EGA yesterday. For me, it seems like the game is trying to load game files when I run around into different zones. What seems to happen first is the minimaps fails to update as i'm moving around. Then I can't interact with things in the world, such as NPCs and Objects. I'm able to wait it out most of the time, it usually takes 5 minutes max. I have to wait for my HDD Led to stop being full constant on and back to the normal blinking.
Dxdiag below if it helps