What the hell is a trinket?
The RELIC and adrenal don't proc the gcd, so you can literally run your fingers across f1-f2-f3-f4 like i do, which takes less than a second, and then cast cain lightning/deathfield. Or thundering blast/chain lightning, or thundering blast / shock, or crushing darkness/affliction. RELICS and Adrenals do not use the gcd.
Or you can use a gaming keyboard, and create a macro key that uses relic + adrenal + an ability all within .1 seconds