A couple other people as well as I are having problems post-this patch as well.
I am having this exact same problem. Was thinking about going back to play the game again, but the same problems you are describing are happening to me. I tried to re-adjust the resolution from the Preferences screen and the entire screen freaked out. Doesn't happen with any other games I play or programs I run. My drivers are fully updated, too. No clue how to fix this problem.