I have Razer Naga, so my keybinds are somewhat unimportant since they are all on my thumb. However, as for layout here it is in general, with specific binds in Spoilers to save space:
Top Bar: DPS abilities that don't require cover, as well as "roll into cover" itself. Basically, I want everything I can use on the run, and what I need to get back into cover available to me.
Cover Bar: All Cover abilities plus default attack. Damage, damage, and MOAR DMG!
Bottom Bar: Stuns, Interrupts, Snares, Debuffs, Situational. It's my escapes and Oh ***** for the most part
I skip button 6 since it is just easier for me to hit 7 than 6. Big thumbs. I still have a few abilities to pick up, so things will get rearranged by 50.